Advanced Organic Chemistry (I)

Part 1. Introduction

Fundamental Organometallic reactions

Part 2. Functional Groups Interconversion

1. Brief review

2. Reduction

3. Oxidation

4. Protective groups

Part 3. Carbon-carbon Single Bond Formation

1. Aromatic substitutions

a. Electrophilic aromatic substitution

b. Nucleophilic aromatic substitution

c. Organometallic way - cross coupling reactions

2. SN2 reactions - enolate chemistry

3. Nucleophilic addition reactions (C=O, 1,2- 1,4-)

4. Radical reactions

5. Cycloaddition and related reactions

6. Miscellaneous

Part 4. Carbon-carbon Multiple Bond Formation

1. Elimination reactions

2. Wittig and related reactions

3. Oligomerization of alkenes and alkynes (organometallic way)

4. Metathesis and metal carbene in organic synthesis

5. Synthesis of aromatic rings and heteroaromatic rings

Part 5. Retrosynthesis Approach

1. Retrosynthesis¬－Disconnection Approach

2. Working examples and total synthesis